There are many different ways to unlock the chest of Isaac. Some people use a key, while others may use a combination or even a fingerprint. However, the most common method is to simply insert a small metal rod into the keyhole and turn it until the lock pops open.
This process is known as picking the lock.
- In order to unlock the chest, you will need to find the key
- The key can be found in one of three places: on top of a bookshelf in the room to the left of the chest, underneath a pillow in the room to the right of the chest, or inside a drawer in the room directly behind the chest
- Once you have found the key, bring it over to the chest and insert it into the lock
- Turn the key until you hear a click, indicating that the lock has been opened
- Lift up onthe lid ofthechest untilitopens fully
- InsideyouwillfindtheitemsthatIsaachasbeenhidingaway!
TBoI Unlocking the chest!
Q: How Do You Unlock the Isaac Chest
There are a few different ways to unlock the Isaac Chest. The first way is to have a character with the Pickpocket skill. This can be done by either picking the lock or using a skeleton key.
The second way is to use the Unrelenting Force shout on the chest. This will cause it to open and you can loot the contents inside. The third way is to use an explosion, such as a fireball, on the chest.
This will also cause it to open and you can loot the contents inside.

Credit: gaming.stackexchange.com
Conclusion
In the game “Binding of Isaac”, there is a chest that can be unlocked if you have the right key. The key is found by defeating the boss named Isaac. Once you have the key, you can unlock the chest and get some valuable items.
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